Variants of the MRGPRX2 Gene Found in Patients With Hypersensitivity to Quinolones and Vancomycin Show Amplified and Drug‐Specific Activation Responses In Vitro

Abstract excerpt

The diagnosis of immediate hypersensitivity reactions (IHDRs) to fluoroquinolones and vancomycin is challenging. Though they may be partially mediated by the immunoglobulin E (IgE) high-affinity receptor in mast cells [1, 2], key features suggest that other mechanisms could be at play [2, 3]. They often occur in drug-naïve individuals [1, 4] receiving first doses of treatment [1, 4], and skin testing results are...

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