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Pharmacogenetic Determinants of Immediate and Delayed Reactions of Drug Hypersensitivity

1 Sept 2008

Abstract excerpt

Drug allergy refers to a hypersensitivity reaction for which either an IgE or T-cell-mediated mechanism is demonstrated. The recognition of the drug by B and T cells is influenced by variants of HLA genes. The genetic factors involved in IgE-mediated mechanisms have been studied mainly in beta-lactam reactions, and they appear to be related to human leukocyte antigen presentation (HLA A2 and DRw52), TNFA -308G>A,...

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PMID: 18991696
DOI: 10.2174/138161208786369795

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