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Article

Next-generation sequencing and genotype association studies reveal the association of HLA-DRB3*02:02 with delayed hypersensitivity to penicillins.

Allergy - 1 Jun 2022

Romano Antonino, Oussalah Abderrahim, Chery Celine, Guéant-Rodriguez Rosa-Maria, Gaeta Francesco, Cornejo-Garcia Jose-Antonio, Rouyer Pierre, Josse Thomas, Mayorga Cristobalina, Torres Maria-Jose, Guéant Jean-Louis

Abstract excerpt

BACKGROUND: Nonimmediate (delayed)-allergic reactions to penicillins are common and some of them can be life-threatening. The genetic factors influencing these reactions are unknown/poorly known/poorly understood. We assessed the genetic predictors of a delayed penicillin allergy that cover the HLA loci. METHODS: Using next-generation sequencing (NGS), we genotyped the MHC region in 24 patients with delayed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34687232
DOI: 10.1111/all.15147

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