Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.

doi:10.1016/j.jaci.2020.10.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.

The Journal of allergy and clinical immunology - 1 May 2021

Nicoletti Paola, Carr Daniel F, Barrett Sarah, McEvoy Laurence, Friedmann Peter S, Shear Neil H, Nelson Matthew R, Chiriac Anca M, Blanca-López Natalia, Cornejo-García José A, Gaeta Francesco, Nakonechna Alla, Torres Maria J, Caruso Cristiano, Valluzzi Rocco L, Floratos Aris, Shen Yufeng, Pavlos Rebecca K, Phillips Elizabeth J, Demoly Pascal, Romano Antonino, Blanca Miguel, Pirmohamed Munir

Abstract excerpt

BACKGROUND: β-lactam antibiotics are associated with a variety of immune-mediated or hypersensitivity reactions, including immediate (type I) reactions mediated by antigen-specific IgE. OBJECTIVE: We sought to identify genetic predisposing factors for immediate reactions to β-lactam antibiotics. METHODS: Patients with a clinical history of immediate hypersensitivity reactions to either penicillins or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cephalosporins

Share to Cohort Studies

Share to Drug Hypersensitivity

Share to HLA-DQ alpha-Chains

Share to HLA-DRB1 Chains

Share to Hypersensitivity, Immediate

Share to Penicillins

Source

Open in PubMed Open full text

Identifiers

PMID: 33058932
DOI: 10.1016/j.jaci.2020.10.004
PMCID: PMC8100096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Beta-lactam-induced immediate hypersensitivity reactions: A genome-wide association study of a deeply phenotyped cohort.PMID 33058932Read ↗

HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.Semantic proximity Read ↗

Next-Generation Sequencing and Genotype Association Studies Reveal the Association of HLA-DRB3*02:02 With Delayed Hypersensitivity to PenicillinsSemantic proximity Read ↗

Next-generation sequencing and genotype association studies reveal the association of HLA-DRB3*02:02 with delayed hypersensitivity to penicillins.Semantic proximity Read ↗

Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy.Semantic proximity Read ↗

Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.Semantic proximity Read ↗

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergySemantic proximity Read ↗

Polymorphisms of HLA genes and hypersensitivity to penicillin among patients in a Taiwanese population.Semantic proximity Read ↗

Update on the Genetic Basis of Drug Hypersensitivity Reactions.Semantic proximity Read ↗

Clinical and genetic risk factors of self-reported penicillin allergy.Semantic proximity Read ↗

Drug Induced Hypersensitivity and the HLA ComplexSemantic proximity Read ↗

Pharmacogenetic Determinants of Immediate and Delayed Reactions of Drug HypersensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.