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Article

Functional Impact of MRGPRX2 Single-Nucleotide Polymorphisms on Drug-Induced Cellular Responses In Vitro.

Frontiers in bioscience (Landmark edition) - 21 May 2026

Dziadowiec Alicja, Kwitniewski Mateusz, Rybka Hubert, Sinkevich Ivan, Porebski Grzegorz

Abstract excerpt

BACKGROUND: Recent evidence indicates that the Mas-related G protein-coupled receptor X2 (MRGPRX2) can be activated by several drugs, including neuromuscular blocking agents, fluoroquinolones, and vancomycin. However, the contribution of this mechanism to drug hypersensitivity reactions (DHRs) observed in clinical practice remains incompletely understood. Single-nucleotide polymorphisms (SNPs) in the MRGPRX2 gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42216540
DOI: 10.31083/FBL51779

Genes

MRGPRX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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