Article
Fe(II) with Tris(1-pyrazolyl)methane Complex Increases Thermal Stability In Vitro and Activity In Vivo of the Mutant 447R Form of Mouse Tryptophan Hydroxylase 2.
International journal of molecular sciences - 10 Apr 2026
Terentieva Ekatherine I, Komleva Polina D, Antonova Sophia M, Moskaliuk Vitalii S, Khotskin Nikita V, Shamshurin Maxim V, Sokolov Maxim N, Kulikov Alexander V
Abstract excerpt
Pharmacological chaperones (PCs)-small molecules that normalize the 3D structure of mutant protein molecules-are promising substances for pharmacological treatment of grave hereditary pathologies. In this study, possible chaperone-like effects of the Fe(II) with tris(1-pyrasolyl)methane complex, [Fe(TPM)2]Cl2, on the mutant 447R form of mouse tryptophan hydroxylase 2 (TPH2) in vitro and in vivo were investigated....
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