Article
Somatic mutations and outcomes in chronic myeloid leukemia adolescent and young adults compared to children, adults, and BCR::ABL1-positive acute lymphoblastic leukemia.
Leukemia - 1 Jul 2025
Krizkova Jitka, Polivkova Vaclava, Laznicka Adam, Curik Nikola, Benesova Adela, Suchankova Pavla, Smazik Tomas, Vysinova Veronika, Mikulenkova Dana, Klamova Hana, Markova Marketa Stastna, Srbova Dana, Zuna Jan, Zaliova Marketa, Trka Jan, Salek Cyril, Polakova Katerina Machova
Abstract excerpt
Adolescent and young adults (AYAs) with chronic myeloid leukemia in chronic phase (CML-CP) reportedly respond worse to tyrosine kinase inhibitors (TKIs) than adults, potentially due to additional genetic abnormalities, including mutations in cancer-related genes (CRGs). This real-life study compared mutation profiles and their impact on outcomes in 80 AYA, 97 adult, and 16 pediatric CML-CP patients, alongside 81...
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