Article

Prevalence and Prognostic Impact of ASXL1 Somatic Mutation in Patients with Chronic Myeloid Leukemia: A Systemic Review and Meta-Analysis

2026-03-23

Abstract excerpt

<h4>Background: </h4> Outcomes in chronic myeloid leukemia (CML) remain heterogeneous despite effective BCR::ABL1 tyrosine kinase inhibitors (TKIs). Somatic mutations in epigenetic regulators, particularly additional sex combs like 1 (ASXL1), have been implicated in adverse prognosis, but their clinical impact in CML has not been systematically defined. <h4>Methods:</h4> A systematic review was conducted using CIN...

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Literature Corpus work: d4dc4c8e-a645-5916-b142-0a988d4a61a4
DOI: 10.20944/preprints202603.1788.v1

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