Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AML

8 Jul 2022

Abstract excerpt

Cytarabine (Ara-C) is the first-line drug for the treatment of acute myelogenous leukemia (AML). However, resistance eventually develops, decreasing the efficacy of Ara-C in AML patients. The expression of SAMHD1, a deoxynucleoside triphosphate (dNTP) triphosphohydrolase, has been reported to be elevated in Ara-C-resistant AML patients and to play a crucial role in mediating Ara-C resistance in AML. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Adenosine and Purinergic Signaling
Share to Autophagy in Disease and Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35803902
DOI: 10.1038/s41419-022-05023-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Stabilization of SAMHD1 by NONO is crucial for Ara-C resistance in AMLPMID 35803902Read ↗

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabineSemantic proximity Read ↗

With me or against me: Tumor suppressor and drug resistance activities of SAMHD1.Semantic proximity Read ↗

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cellsSemantic proximity Read ↗

SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabineSemantic proximity Read ↗

Effect of NME2 and SAMHD1 genetic polymorphisms involved in Ara-C metabolism on the response to induction chemotherapy in adult acute myeloid leukemia.Semantic proximity Read ↗

Differences between intrinsic and acquired nucleoside analogue resistance in acute myeloid leukaemia cellsSemantic proximity Read ↗

KDM4C contributes to cytarabine resistance in acute myeloid leukemia via regulating the miR-328-3p/CCND2 axis through MALAT1Semantic proximity Read ↗

Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML).Semantic proximity Read ↗

Long noncoding RNA DANCR confers cytarabine resistance in acute myeloid leukemia by activating autophagy via the miR‐874‐3P/ATG16L1 axisSemantic proximity Read ↗

SAMHD1 single nucleotide polymorphisms impact outcome in children with newly diagnosed acute myeloid leukemia.Semantic proximity Read ↗

Genome-wide CRISPR/Cas9 screen identifies AraC-daunorubicin-etoposide response modulators associated with outcomes in pediatric AMLSemantic proximity Read ↗

Clofarabine exerts antileukemic activity against cytarabine-resistant B-cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.