Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation.

mBio - 21 Dec 2021

Mohammadzadeh Nazanin, Roda Weston, Branton William G, Clain Julien, Rabezanahary Henintsoa, Zghidi-Abouzid Ouafa, Gelman Benjamin B, Angel Jonathan B, Cohen Eric A, Gill M John, Li Michael, Estaquier Jérome, Power Christopher

Abstract excerpt

HIV infection persists in different tissue reservoirs among people with HIV (PWH) despite effective antiretroviral therapy (ART). In the brain, lentiviruses replicate principally in microglia and trafficking macrophages. The impact of ART on this viral reservoir is unknown. We investigated the activity of contemporary ART in various models of lentivirus brain infection. HIV-1 RNA and total and integrated DNA were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-HIV Agents
Share to Macaca mulatta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macrophages

Share to Microglia

Share to Proviruses

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Virus Latency

Source

Open in PubMed Open full text

Identifiers

PMID: 34903055
DOI: 10.1128/mBio.02784-21
PMCID: PMC8669467

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lentiviral Infections Persist in Brain despite Effective Antiretroviral Therapy and Neuroimmune Activation.PMID 34903055Read ↗

Is the Central Nervous System Reservoir a Hurdle for an HIV Cure?Semantic proximity Read ↗

Microglia Exhibit a Unique Intact HIV Reservoir in Human Postmortem Brain TissueSemantic proximity Read ↗

Reactivation of simian immunodeficiency virus reservoirs in the brain of virally suppressed macaquesSemantic proximity Read ↗

Opioid-induced immunosuppression of brain myeloid cells in SIV-infected rhesus macaquesSemantic proximity Read ↗

Human microglia phenotypes in the brain associated with HIV infection.Semantic proximity Read ↗

The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection.Semantic proximity Read ↗

Microglia and macrophages alterations in the CNS during acute SIV infection: A single-cell analysis in rhesus macaquesSemantic proximity Read ↗

Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIVSemantic proximity Read ↗

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaquesSemantic proximity Read ↗

HIV-1–infected T cell clones are shared across cerebrospinal fluid and blood during ARTSemantic proximity Read ↗

Opioid-induced transcriptional reprogramming of cerebrospinal fluid immune cells drives neuroinflammation in SIV-infected rhesus macaquesSemantic proximity Read ↗

Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.