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Chromosomal instability in human trophoblast stem cells and placentas

25 Apr 2025

Abstract excerpt

The human placenta, a unique tumor-like organ, is thought to exhibit rare aneuploidy associated with adverse pregnancy outcomes. Discrepancies in reported aneuploidy prevalence in placentas stem from limitations in modeling and detection methods. Here, we use isogenic trophoblast stem cells (TSCs) derived from both naïve and primed human pluripotent stem cells (hPSCs) to reveal the spontaneous occurrence of...

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PMID: 40280964
DOI: 10.1038/s41467-025-59245-9

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