Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype.

Developmental biology - 15 Mar 2005

Weier Jingly F, Weier Heinz-Ulrich G, Jung Christine J, Gormley Matthew, Zhou Yan, Chu Lisa W, Genbacev Olga, Wright Alexi A, Fisher Susan J

Abstract excerpt

Through an unusual differentiation process, human trophoblast progenitors (cytotrophoblasts) give rise to tumor-like cells that invade the uterus. By an unknown mechanism, invasive cytotrophoblasts exhibit permanent cell cycle withdrawal. Here, we report molecular cytogenetic data showing that approximately 20 to 60% of these interphase cells had acquired aneusomies involving chromosomes X, Y, or 16. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, X

Share to Chromosomes, Human, Y

Share to Cytogenetic Analysis

Share to Gestational Age

Share to Placenta

Share to Trophoblasts

Source

Identifiers

PMID: 15733669
DOI: 10.1016/j.ydbio.2004.12.035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human cytotrophoblasts acquire aneuploidies as they differentiate to an invasive phenotype.PMID 15733669Read ↗

Developmental potential of aneuploid human embryos cultured beyond implantationSemantic proximity Read ↗

Chromosomal instability in human trophoblast stem cells and placentasSemantic proximity Read ↗

Genome amplification and cellular senescence are hallmarks of human placenta developmentSemantic proximity Read ↗

Human Embryonic Stem Cells as Models for Aneuploid Chromosomal SyndromesSemantic proximity Read ↗

Aneuploidy 16 in human embryos increases significantly with maternal ageSemantic proximity Read ↗

DNA Microarray Reveals That High Proportions of Human Blastocysts from Women of Advanced Maternal Age Are Aneuploid and Mosaic1Semantic proximity Read ↗

Previously reported and here added cases demonstrate euploid pregnancies followed by PGT-A as “mosaic” as well as “aneuploid” designated embryosSemantic proximity Read ↗

Trisomy 21 is associated with variable defects in cytotrophoblast differentiation along the invasive pathway.Semantic proximity Read ↗

Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structureSemantic proximity Read ↗

Segmental aneuploidy in human blastocysts: a qualitative and quantitative overviewSemantic proximity Read ↗

Chromosome mosaicism in day 3 aneuploid embryos that develop to morphologically normal blastocysts in vitroSemantic proximity Read ↗

Modelling a risk classification of aneuploidy in human embryos using non-invasive morphokinetics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.