Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transforming malignant tumors into vulnerable phenotypes via nanoscale coordination polymer mediated cell senescence and photodynamic therapy.

Biomaterials - 1 Nov 2025

Zhen Wenyao, Jiang Xiaomin, Li En, Germanas Tomas, Lee Morten J, Luo Taokun, Ma Xin, Wang Chaoyu, Chen Yimei, Weichselbaum Ralph R, Lin Wenbin

Abstract excerpt

Induction of senescence in cancer cells can thwart the proliferation of malignant tumors. Herein we report the design of AZT-P/pyro nanoscale coordination polymer particles consisting of 3-azido-2,3-dideoxythymidine monophosphate (AZT-P) in the core and photosensitizing pyro-lipid (pyro) in the shell for potent antitumor treatment. Gradual release of AZT-P in response to an acidic tumor microenvironment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nanoparticles

Share to Neoplasms

Share to Photochemotherapy

Share to Photosensitizing Agents

Share to Polymers

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 40279766
DOI: 10.1016/j.biomaterials.2025.123355
PMCID: PMC12140873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transforming malignant tumors into vulnerable phenotypes via nanoscale coordination polymer mediated cell senescence and photodynamic therapy.PMID 40279766Read ↗

Optimized Bionic Drug Delivery Inducing Immunogenic Cell Death and cGAS-STING Pathway Activation for Enhanced Photochemotherapy-Driven Immunotherapy in Prostate CancerSemantic proximity Read ↗

From Phenomenon to Precision: Addressing Key Challenges in Harnessing Nanomaterial-Induced Biological Responses for Cancer TherapySemantic proximity Read ↗

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancerSemantic proximity Read ↗

Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis.Semantic proximity Read ↗

Induction of complementary immunogenic necroptosis and apoptosis cell death pathways inhibits cancer metastasis and relapseSemantic proximity Read ↗

Endogenous/Exogenous Nanovaccines Synergistically Enhance Dendritic Cell-mediated Tumor ImmunotherapySemantic proximity Read ↗

Bi-Target Nanomodulator for Glioma-Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH-Mutant Gliomas.Semantic proximity Read ↗

A homologous-targeting "nanoconverter" with variable size for deep tumor penetration and immunotherapy.Semantic proximity Read ↗

Engineered MoS₂ Nanoplatforms for Drug-Enhanced Cancer Phototherapy: From Design Strategies to Translational OpportunitiesSemantic proximity Read ↗

Tumor Microenvironment-Responsive CA@ZIF-8/MnO 2 Nanoreactor for Self-Reinforcing Cascade Chemodynamic Therapy and ImmunomodulationSemantic proximity Read ↗

A highly effective self-supplying photosensitizer drug for deep-tissue metastatic tumours treatmentSemantic proximity Read ↗

Electrostatically Assembled CaO2@MPN-HA Nanoreactors Potentiate Anti-PD-1 Therapy in Thyroid Cancer via Synergistic Ferroptosis and Calcium OverloadSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.