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Optimized Bionic Drug Delivery Inducing Immunogenic Cell Death and cGAS-STING Pathway Activation for Enhanced Photochemotherapy-Driven Immunotherapy in Prostate Cancer

2024-03-13

Abstract excerpt

Prostate cancer (PCa) presents a challenging disease as it is often characterized as an immunologically “cold” tumor, leading to suboptimal outcomes with current immunotherapeutic approaches in clinical settings. Photodynamic therapy (PDT) harnesses reactive oxygen species generated by photosensitizers (PSs) to disrupt intracellular redox equilibrium. This process induces DNA damage in both the mitochondria and nu...

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Literature Corpus work: ee3e8eb0-5129-5b51-aa0d-81d4d89f41e5
DOI: 10.21203/rs.3.rs-4019977/v1

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