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Tumor Microenvironment-Responsive CA@ZIF-8/MnO 2 Nanoreactor for Self-Reinforcing Cascade Chemodynamic Therapy and Immunomodulation

2025-05-22

Abstract excerpt

<title>Abstract</title> <p>Chemodynamic therapy (CDT), which utilizes endogenous hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) to generate hydroxyl radicals (<sup><bold>•</bold></sup>OH) via Fenton-like reactions, faces critical limitations in clinical translation, including insufficient intratumoral H<sub>2</sub>O<sub>2</sub> levels and glutathione (GSH)-mediated ROS scavenging. To address these challenges, we...

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Literature Corpus work
b6d9ce40-be2f-5538-8257-845f16dc0779
DOI
10.21203/rs.3.rs-6676160/v1
Open publication

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