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Article

Bioengineering of BRAF and COX2 inhibitor nanogels to boost the immunotherapy of melanoma via pyroptosis.

Chemical communications (Cambridge, England) - 19 Jan 2023

Zhang Meng-Jie, Liang Meng-Yun, Yang Shao-Chen, Ma Xian-Bin, Wan Shu-Cheng, Yang Qi-Chao, Wang Shuo, Xu Zhigang, Sun Zhi-Jun

Abstract excerpt

Glutathione-responsive nanogels (CDNPs) crosslinked via crosslinker DBHD with the BRAF inhibitor dabrafenib and the COX2 inhibitor celecoxib were fabricated. The CDNPs can effectively induce tumor cell pyroptosis to activate robust antitumor immunity. Additionally, CDNPs combined with αPD-1 antibody greatly inhibited tumor growth in a melanoma mouse model with a prolonged survival time.

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Identifiers

PMID: 36597866
DOI: 10.1039/d2cc05498a

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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