Article
Bi-Target Nanomodulator for Glioma-Associated Myeloid Cells Polarization by Inducing Pyroptosis and Regulating Tryptophan Metabolism to Reshape Immunosuppressive Microenvironment of IDH-Mutant Gliomas.
Advanced materials (Deerfield Beach, Fla.) - 1 Apr 2026
Bai Shiqi, Li Wanying, Yin Na, Cao Yue, Zhang Shaopeng, Wang Ziqian, Qu Donghao, Wang Bin, Li Yunqian, Liu Xinrui, Jiang Yanfang, Wang Yinghui
Abstract excerpt
Since 2-hydroxyglutarate (2-HG) released from isocitrate dehydrogenase (IDH)-mutant gliomas results in the strong immunosuppressive tumor microenvironment (TME), the immunotherapy effect is unsatisfactory. In this work, we develop a hybridized cell membrane of glioma-macrophage cells (GMM) camouflaged bi-target nanomodulator (LNO@CH/Ca3(PO4)2, LCC) comprised of LaNiO3 (LNO) core and Ca3(PO4)2 shell loaded with...
Topics
Join the communities discussing this publication.