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Article

CD8+T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in acute myeloid leukemia (AML) patients.

Clinical immunology (Orlando, Fla.) - 1 May 2018

Wang Mengjie, Bu Jin, Zhou Maohua, Sido Jessica, Lin Yu, Liu Guanfang, Lin Qiwen, Xu Xiuzhang, Leavenworth Jianmei W, Shen Erxia

Abstract excerpt

Acute myeloid leukemia (AML) is one of the most common types of leukemia among adults with an overall poor prognosis and very limited treatment management. Immune checkpoint blockade of PD-1 alone or combined with other immune checkpoint blockade has gained impressive results in murine AML models by improving anti-leukemia CD8+T cell function, which has greatly promoted the strategy to utilize combined immune...

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Share to Antigens, Differentiation, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Induction Chemotherapy

Share to Leukemia, Myeloid

Share to Programmed Cell Death 1 Receptor

Share to Receptors, Immunologic

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Source

Identifiers

PMID: 28893624
DOI: 10.1016/j.clim.2017.08.021

Genes

TIGIT
FLT3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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