Article
Differences in renal cortex transcriptional profiling of wild-type and novel type B cystinuria model rats.
Urolithiasis - 1 Jun 2022
Zhang Zihan, Zheng Rui, Chen Zhoutong, Zhan Xia, Fang Xiaoliang, Liu Meizhen, Li Yongmei, Xu Yonghu, Li Dali, Geng Hongquan, Zhang Xiaohui, Xu Guofeng
Abstract excerpt
Cystinuria is a genetic disorder of cystine transport that accounts for 1-2% of all cases of renal lithiasis. It is characterized by hyperexcretion of cystine in urine and recurrent cystine lithiasis. Defective transport of cystine into epithelial cells of renal tubules occurs because of mutations of the transport heterodimer, including protein b0,+AT (encoded by SLC7A9) and rBAT (encoded by SLC3A1) linked...
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