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Article

Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study.

Clinical and translational science - 1 Apr 2025

Conyers Rachel, Stenta Tayla, Somogyi Andrew A, Kirkpatrick Carl, Halman Andreas, Wang Sophie, Moore Claire, Khatri Dhrita, Williams Elizabeth, Dyas Roxanne, Spelman Tim, Elliott David A, Gwee Amanda, Alexander Marliese

Abstract excerpt

Phenoconversion is the discrepancy between genotype-predicted phenotype and clinical phenotype, due to nongenetic factors. In oncology patients, the impact of phenoconversion on drug selection, efficacy, toxicity, and treatment outcomes is unknown. This study will assess acceptability and feasibility of investigating phenoconversion using probe medications in a pediatric and adolescent and young adult (AYA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40259519
DOI: 10.1111/cts.70209
PMCID: PMC12011636

Genes

CYP2C19
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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Phenoconversion of CYP3A4, CYP2C19 and CYP2D6 in Pediatrics, Adolescents and Young Adults With Lymphoma: Rationale and Design of the PEGASUS Study.PMID 40259519Read ↗

Protocol for a prospective feasibility study investigating phenoconversion of<i>CYP3A4</i>,<i>CYP2C19</i>and<i>CYP2D6</i>genotypes in paediatric and adolescent and young adult patients with an acute diagnosis of Hodgkin or Non-Hodgkin Lymphoma [PEGASUS]Semantic proximity Read ↗

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