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Article

Addressing phenoconversion: the Achilles' heel of personalized medicine.

British journal of clinical pharmacology - 1 Feb 2015

Shah Rashmi R, Smith Robert L

Abstract excerpt

Phenoconversion is a phenomenon that converts genotypic extensive metabolizers (EMs) into phenotypic poor metabolizers (PMs) of drugs, thereby modifying their clinical response to that of genotypic PMs. Phenoconversion, usually resulting from nongenetic extrinsic factors, has a significant impact on the analysis and interpretation of genotype-focused clinical outcome association studies and personalizing therapy...

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Share to Cytochrome P-450 CYP2D6
Share to Dose-Response Relationship, Drug
Share to Drug Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

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Share to Pharmacogenetics

Share to Polymorphism, Genetic

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Identifiers

PMID: 24913012
DOI: 10.1111/bcp.12441
PMCID: PMC4309629

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