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Article

How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.

Clinical pharmacology and therapeutics - 1 Sept 2021

Cicali Emily J, Elchynski Amanda L, Cook Kelsey J, Houder John T, Thomas Cameron D, Smith D Max, Elsey Amanda, Johnson Julie A, Cavallari Larisa H, Wiisanen Kristin

Abstract excerpt

CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype-based phenotype, a process referred to as phenoconversion. Phenoconversion is highly prevalent but not widely integrated into practice because of...

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Identifiers

PMID: 34231197
DOI: 10.1002/cpt.2354
PMCID: PMC8404400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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