Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decoding heterogeneous and coordinated tissue architecture in glioblastoma using spatial transcriptomics

20 May 2024

Abstract excerpt

Glioblastoma multiforme (GBM) is one of the most lethal brain tumors, characterized by profound heterogeneity. While single-cell transcriptomic studies have revealed extensive intra-tumor heterogeneity, shed light on intra-tumor diversity, spatial intricacies remain largely unexplored. Leveraging clinical GBM specimens, this study employs spatial transcriptomics technology to delve into gene expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell Image Analysis Techniques
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38947514
DOI: 10.1016/j.isci.2024.110064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decoding heterogeneous and coordinated tissue architecture in glioblastoma using spatial transcriptomicsPMID 38947514Read ↗

Single-cell and spatial transcriptomic insights into glioma cellular heterogeneity and metabolic adaptationsSemantic proximity Read ↗

Spatially Integrated Multi-Omics reveals the Multicellular Landscape of Progenitor-Driven Glioblastoma ProgressionSemantic proximity Read ↗

A spatially resolved human glioblastoma atlas reveals distinct cellular and molecular patterns of anatomical nichesSemantic proximity Read ↗

Spatial transcriptomics reveals segregation of tumor cell states in glioblastoma and marked immunosuppression within the perinecrotic nicheSemantic proximity Read ↗

Histology and spatial transcriptomic integration revealed infiltration zone with specific cell composition as a prognostic hotspot in glioblastomaSemantic proximity Read ↗

Charting the single-cell and spatial landscape of IDH-wild-type glioblastoma with GBmapSemantic proximity Read ↗

Mapping the Stemness Landscape of Glioblastoma to Drive Heterogeneity and Drug Resistance: Bridging Pathological Omics with Prognostic OutcomesSemantic proximity Read ↗

Local Tumor Microenvironment Niches Correlate With Survival And Immunotherapy Response In Human GlioblastomaSemantic proximity Read ↗

Harmonized single-cell landscape, intercellular crosstalk and tumor architecture of glioblastomaSemantic proximity Read ↗

Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell linesSemantic proximity Read ↗

Multi-transcriptomics reveals niche-specific expression programs and endothelial cells in glioblastomaSemantic proximity Read ↗

Mapping the spatial architecture of glioblastoma from core to edge delineates niche-specific tumor cell states and intercellular interactionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.