A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses.

Abstract excerpt

Most mosquito-transmitted alphaviruses encode a premature opal termination codon upstream of their viral polymerase. We show that the Sindbis virus (SINV) opal codon outperforms other stop codons in primate cells at 37°C due to optimal translational readthrough. However, increased readthrough of all stop codons reduces opal preference at 28°C in primate and mosquito cells. Opal also outperforms all sense codons...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alphavirus
• Share to Codon, Terminator