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Article

Identification novel mutations in TUBB8 in female infertility and a novel phenotype of large polar body in oocytes with TUBB8 mutations.

Journal of assisted reproduction and genetics - 1 Aug 2020

Zhao Lin, Guan Yichun, Wang Wenjing, Chen Biaobang, Xu Shiru, Wu Ling, Yan Zheng, Li Bin, Fu Jing, Shi Rong, Shi Juanzi, Du Jing, Li Qiaoli, Zhang Zhihua, Mu Jian, Zhou Zhou, Dong Jie, Jin Li, He Lin, Sun Xiaoxi, Kuang Yanping, Wang Lei, Sang Qing

Abstract excerpt

PURPOSE: We aimed to identify novel variants in TUBB8 and corresponding new abnormal phenotypes in oocytes/fertilization/ embryonic development responsible for female infertility. METHODS: Sanger sequencing of TUBB8 was performed in infertile women with abnormalities in oocyte maturation or embryonic development. The effects of the variants were evaluated in patients' oocytes by morphological observations and...

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Embryo Implantation
Embryonic Development
Infertility, Female
Oocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32524331
DOI: 10.1007/s10815-020-01830-6
PMCID: PMC7468027

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