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Article

Selective expression of Pneumocystis antigens in different patients during a suspected outbreak of Pneumocystis pneumonia.

mBio - 14 May 2025

Meier Caroline S, Pagni Marco, Richard Sophie, Mühlethaler Konrad, Hauser Philippe M

Abstract excerpt

The fungus Pneumocystis jirovecii causes severe pneumonia in immunocompromised individuals. It harbors a system of surface antigenic variation involving six families of major surface glycoproteins (Msg). We determined the repertoires of P. jirovecii msg genes of the most abundant family-I present in 15 Swiss patients with Pneumocystis pneumonia (PCP) enrolled randomly. The highly repetitive msg-I genes were...

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Identifiers

PMID: 40243367
DOI: 10.1128/mbio.00692-25
PMCID: PMC12077189

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