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Diversity of Pneumocystis jirovecii during Infection Revealed by Ultra-Deep Pyrosequencing

24 May 2016

Abstract excerpt

Pneumocystis jirovecii is an uncultivable fungal pathogen responsible for Pneumocystis pneumonia (PCP) in immunocompromised patients, the physiopathology of which is only partially understood. The diversity of the Pneumocystis strains associated with acute infection has mainly been studied by Sanger sequencing techniques precluding any identification of rare genetic events (< 20% frequency). We used...

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PMID: 27252684
DOI: 10.3389/fmicb.2016.00733

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