Article
Variation in the major surface glycoprotein genes in Pneumocystis jirovecii.
The Journal of infectious diseases - 1 Sept 2008
Kutty Geetha, Maldarelli Frank, Achaz Guillaume, Kovacs Joseph A
Abstract excerpt
The genome of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface glycoprotein (Msg). Pneumocystis can vary the expressed Msg, presumably as a mechanism to avoid host immune responses. Analysis of 24 msg-gene sequences obtained from a single human isolate of Pneumocystis demonstrated that the sequences segregate into 2...
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