Article
Expression Pattern of the Pneumocystis jirovecii Major Surface Glycoprotein Superfamily in Patients with Pneumonia.
The Journal of infectious diseases - 3 Feb 2021
Schmid-Siegert Emanuel, Richard Sophie, Luraschi Amanda, Mühlethaler Konrad, Pagni Marco, Hauser Philippe M
Abstract excerpt
BACKGROUND: The human pathogen Pneumocystis jirovecii harbors 6 families of major surface glycoproteins (MSGs) encoded by a single gene superfamily. MSGs are presumably responsible for antigenic variation and adhesion to host cells. The genomic organization suggests that a single member of family I is expressed at a given time per cell, whereas members of the other families are simultaneously expressed. METHODS:...
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