Article
Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology.
Nature genetics - 1 Dec 2017
Ferreira Manuel A, Vonk Judith M, Baurecht Hansjörg, Marenholz Ingo, Tian Chao, Hoffman Joshua D, Helmer Quinta, Tillander Annika, Ullemar Vilhelmina, van Dongen Jenny, Lu Yi, Rüschendorf Franz, Esparza-Gordillo Jorge, Medway Chris W, Mountjoy Edward, Burrows Kimberley, Hummel Oliver, Grosche Sarah, Brumpton Ben M, Witte John S, Hottenga Jouke-Jan, Willemsen Gonneke, Zheng Jie, Rodríguez Elke, Hotze Melanie, Franke Andre, Revez Joana A, Beesley Jonathan, Matheson Melanie C, Dharmage Shyamali C, Bain Lisa M, Fritsche Lars G, Gabrielsen Maiken E, Balliu Brunilda, Nielsen Jonas B, Zhou Wei, Hveem Kristian, Langhammer Arnulf, Holmen Oddgeir L, Løset Mari, Abecasis Gonçalo R, Willer Cristen J, Arnold Andreas, Homuth Georg, Schmidt Carsten O, Thompson Philip J, Martin Nicholas G, Duffy David L, Novak Natalija, Schulz Holger, Karrasch Stefan, Gieger Christian, Strauch Konstantin, Melles Ronald B, Hinds David A, Hübner Norbert, Weidinger Stephan, Magnusson Patrik K E, Jansen Rick, Jorgenson Eric, Lee Young-Ae, Boomsma Dorret I, Almqvist Catarina, Karlsson Robert, Koppelman Gerard H, Paternoster Lavinia
Abstract excerpt
Asthma, hay fever (or allergic rhinitis) and eczema (or atopic dermatitis) often coexist in the same individuals, partly because of a shared genetic origin. To identify shared risk variants, we performed a genome-wide association study (GWAS; n = 360,838) of a broad allergic disease phenotype that considers the presence of any one of these three diseases. We identified 136 independent risk variants (P < 3 ×...
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