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Article

Shared genetic architecture between gastro-esophageal reflux disease, asthma, and allergic diseases.

Communications biology - 2 Sept 2024

Gong Tong, Kuja-Halkola Ralf, Harder Arvid, Lundholm Cecilia, Smew Awad I, Lehto Kelli, Andreasson Anna, Lu Yi, Talley Nicholas J, Pasman Joëlle A, Almqvist Catarina, Brew Bronwyn K

Abstract excerpt

The aim is to investigate the evidence for shared genetic architecture between each of asthma, allergic rhinitis and eczema with gastro-esophageal reflux disease (GERD). Structural equation models (SEM) and polygenic risk score (PRS) analyses are applied to three Swedish twin cohorts (n = 46,582) and reveal a modest genetic correlation between GERD and asthma of 0.18 and bidirectional PRS and phenotypic...

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Identifiers

PMID: 39223263
DOI: 10.1038/s42003-024-06795-1
PMCID: PMC11369275

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