Article
Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions.
Translational psychiatry - 12 Apr 2025
Fanelli Giuseppe, Franke Barbara, Fabbri Chiara, Werme Josefin, Erdogan Izel, De Witte Ward, Poelmans Geert, Ruisch I Hyun, Reus Lianne Maria, van Gils Veerle, Jansen Willemijn J, Vos Stephanie J B, Alam Kazi Asraful, Martinez Aurora, Haavik Jan, Wimberley Theresa, Dalsgaard Søren, Fóthi Ábel, Barta Csaba, Fernandez-Aranda Fernando, Jimenez-Murcia Susana, Berkel Simone, Matura Silke, Salas-Salvadó Jordi, Arenella Martina, Serretti Alessandro, Mota Nina Roth, Bralten Janita
Abstract excerpt
The co-occurrence of insulin resistance (IR)-related metabolic conditions with neuropsychiatric disorders is a major public health challenge. Evidence of the genetic links between these phenotypes is emerging, but little is currently known about the genomic regions and biological functions that are involved. To address this, we performed Local Analysis of [co]Variant Association (LAVA) using large-scale...
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