Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of disease and species differences on the intestinal CLCA4 gene expression

12 Apr 2025

Abstract excerpt

The human chloride channel regulator, calcium-activated (CLCA) 4 is discussed as a driver of epithelial-to-mesenchymal transition as well as a biomarker for colorectal cancer (CRC) and ulcerative colitis. In contrast to humans, the Clca4 gene is duplicated in the mouse, a common model species to study gene functions. However, the relevance of the functional murine Clca4 variants in healthy and diseased intestine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Celiac Disease Research and Management
Share to Gastrointestinal motility and disorders
Share to Helicobacter pylori-related gastroenterology studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40220130
DOI: 10.1007/s00109-025-02538-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of disease and species differences on the intestinal CLCA4 gene expressionPMID 40220130Read ↗

Molecular pathways driving disease-specific alterations of intestinal epithelial cells.Semantic proximity Read ↗

CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathwaySemantic proximity Read ↗

Characterisation of colonic dysplasia-like epithelial atypia in murine colitis.Semantic proximity Read ↗

CFTR is a tumor suppressor gene in murine and human intestinal cancer.Semantic proximity Read ↗

Epithelial CRL4 DCAF2 is critical for maintaining intestinal homeostasis by regulating the proliferation and repair of intestinal epithelial cellsSemantic proximity Read ↗

Genetically induced mouse model for colon-specific epithelial cell tumorigenesis driven by loss of K8 and ApcSemantic proximity Read ↗

Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.Semantic proximity Read ↗

CFTR and Gastrointestinal Cancers: An UpdateSemantic proximity Read ↗

The Expression of the Claudin Family of Proteins in Colorectal CancerSemantic proximity Read ↗

The downregulation of tight junction proteins and pIgR in the colonic epithelium causes the susceptibility of EpCAM+/− mice to colitis and gut microbiota dysbiosisSemantic proximity Read ↗

Keratin intermediate filaments in the colon: guardians of epithelial homeostasisSemantic proximity Read ↗

Mouse Models of Human Claudin-Associated Disorders: Benefits and Limitations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.