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Investigating Pfk13 mutations in Plasmodium falciparum natural populations from two malaria-endemic areas of Cameroon.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 2 Sept 2025

Milong Melong Charlotte S, Kojom Foko Loick P, Nkemngo Francis N, Ndo Cyrille, Amvongo-Adjia Nathalie, Russo Gianluca, Tamgue Ousman, Tchoumbougnang François, Morse Daniel P, Paganotti Giacomo M

Abstract excerpt

BACKGROUND: The emergence of Plasmodium falciparum resistance to artemisinin is a huge concern in Africa. We investigated and characterized mutations of Pfk13 propeller sequences from P. falciparum isolates across two endemic areas with different eco-geographical settings in Cameroon. METHODS: A total of 259 dried blood spot samples were collected through a cross-sectional survey in two health facilities located...

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PMID: 40219818
DOI: 10.1093/trstmh/traf040

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