Natural killer cells' functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes.

doi:10.1038/s41467-025-58662-0

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Article

Natural killer cells' functional impairment drives the immune escape of pre-malignant clones in early-stage myelodysplastic syndromes.

Nature communications - 11 Apr 2025

Rodriguez-Sevilla Juan Jose, Ganan-Gomez Irene, Kumar Bijender, Thongon Natthakan, Ma Feiyang, Chien Kelly S, Kim Yi J, Yang Hui, Loghavi Sanam, Tan Roselyn, Adema Vera, Li Zongrui, Tanaka Tomoyuki, Uryu Hidetaka, Kanagal-Shamanna Rashmi, Al-Atrash Gheath, Bejar Rafael, Banerjee Pinaki Prosad, Lynn Cha Sophia, Montalban-Bravo Guillermo, Dougherty Max, Fernandez Laurita Maria Claudina, Wheeler Noelle, Jia Baosen, Papapetrou Eirini P, Izzo Franco, Dueñas Daniela E, McAllen Salome, Gu Yiqian, Todisco Gabriele, Ficara Francesca, Della Porta Matteo Giovanni, Jain Abhinav, Takahashi Koichi, Clise-Dwyer Karen, Halene Stephanie, Bertilaccio Maria Teresa Sabrina, Garcia-Manero Guillermo, Daher May, Colla Simona

Abstract excerpt

Dissecting the preneoplastic disease states' biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic stem cells (HSCs), most of which are mutated by the time of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40216768
DOI: 10.1038/s41467-025-58662-0
PMCID: PMC11992119

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