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Article

Smad7 is a negative regulator of immunogenic cell death in colorectal cancer

11 Apr 2025

Abstract excerpt

Induction of endoplasmic reticulum (ER) stress is followed by exposure of calreticulin (CRT) on the cancer cell plasma membrane and elicits an anticancer immune response, referred to as immunogenic cell death (ICD). Smad7 is highly expressed by colorectal cancer (CRC) cells, and its knockdown with a specific antisense oligonucleotide (AS) induces ER stress. We hypothesized that, by preventing ER stress, high...

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PMID: 40213961
DOI: 10.1080/2162402x.2025.2490346

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