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Article

Smad7 Sustains Stat3 Expression and Signaling in Colon Cancer Cells

12 Oct 2022

Abstract excerpt

Colorectal cancer (CRC) cells contain elevated levels of active signal transducer and the activator of transcription (Stat)-3, which exerts proliferative and anti-apoptotic effects. Various molecules produced in the CRC tissue can activate Stat3, but the mechanisms that amplify such an activation are yet to be determined. In this paper, we assessed whether Smad7, an inhibitor of Transforiming Growth Factor...

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PMID: 36291778
DOI: 10.3390/cancers14204993

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