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Article

Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.

The Journal of biological chemistry - 20 Jan 2012

Materia Stephanie, Cater Michael A, Klomp Leo W J, Mercer Julian F B, La Fontaine Sharon

Abstract excerpt

ATP7A and ATP7B are copper-transporting P(1B)-type ATPases (Cu-ATPases) that are critical for regulating intracellular copper homeostasis. Mutations in the genes encoding ATP7A and ATP7B lead to copper deficiency and copper toxicity disorders, Menkes and Wilson diseases, respectively. Clusterin and COMMD1 were previously identified as interacting partners of these Cu-ATPases. In this study, we confirmed that...

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Identifiers

PMID: 22130675
DOI: 10.1074/jbc.M111.302216
PMCID: PMC3268409

Genes

COMMD1

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Clusterin and COMMD1 independently regulate degradation of the mammalian copper ATPases ATP7A and ATP7B.PMID 22130675Read ↗

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