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Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

9 Apr 2025

Abstract excerpt

Although an increased risk of the skin cancer melanoma in people with Parkinson's disease (PD) has been shown in multiple studies, the mechanisms involved are poorly understood, but increased expression of the PD-associated protein alpha-synuclein (αSyn) in melanoma cells may be important. Our previous work suggests that αSyn can facilitate DNA double-strand break (DSB) repair, promoting genomic stability. We now...

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PMID: 40203113
DOI: 10.1126/sciadv.adq2519

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