Article
Parkin regulates translesion DNA synthesis in response to UV radiation.
Oncotarget - 30 May 2017
Zhu Xuefei, Ma Xiaolu, Tu Yingfeng, Huang Min, Liu Hongmei, Wang Fengli, Gong Juanjuan, Wang Jiuqiang, Li Xiaoling, Chen Qian, Shen Hongyan, Zhu Shu, Wang Yun, Liu Yang, Guo Caixia, Tang Tie-Shan
Abstract excerpt
Deficiency of Parkin is a major cause of early-onset Parkinson's disease (PD). Notably, PD patients also exhibit a significantly higher risk in melanoma and other skin tumors, while the mechanism remains largely unknown. In this study, we show that depletion of Parkin causes compromised cell viability and genome stability after ultraviolet (UV) radiation. We demonstrate that Parkin promotes efficient...
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