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Article

Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

29 Jul 2019

Abstract excerpt

Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its function in the nucleus is not well understood. We demonstrate that alpha-synuclein modulates DNA repair. First, alpha-synuclein colocalizes with DNA damage response components within discrete foci in human cells and mouse brain. Removal...

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PMID: 31358782
DOI: 10.1038/s41598-019-47227-z

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