Article

Alpha-synuclein regulates the repair of genomic DNA double-strand breaks in a DNA-PK <sub>cs</sub> -dependent manner

2024-03-04

Abstract excerpt

α-synuclein (αSyn) is a presynaptic and nuclear protein that aggregates in important neurodegenerative diseases such as Parkinson’s Disease (PD), Parkinson’s Disease Dementia (PDD) and Lewy Body Dementia (LBD). Our past work suggests that nuclear αSyn may regulate forms of DNA double-strand break (DSB) repair in HAP1 cells after DNA damage induction with the chemotherapeutic agent bleomycin 1 . Here, we report th...

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Identifiers and source

Literature Corpus work: 11f7ddc6-418a-5218-b38c-da21f5de1f41
DOI: 10.1101/2024.02.29.582819

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