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Article

Somatic Mutations and Mutation Burden Predict Treatment Response and Survival in Adult Acquired Pure Red Cell Aplasia.

American journal of hematology - 1 Jul 2026

Yang Liyan, Zhang Huiqin, Wei Yansong, Niu Haiyue, Liu Yumei, Zhang Tian, Xing Limin, Shao Zonghong, Fu Rong, Wang Huaquan

Abstract excerpt

Immunosuppressive therapy (IST) is the standard treatment for acquired pure red cell aplasia (aPRCA), but predictors of treatment response and long-term prognosis remain unclear. The clinical significance of somatic mutations in aPRCA is not fully understood. We retrospectively analyzed 69 adult aPRCA patients who underwent targeted next-generation sequencing of 69 genes associated with clonal hematopoiesis and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41922159
DOI: 10.1002/ajh.70311

Genes

DNMT3A
TET2
TP53
ASXL1
GATA2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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