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Article

MYO1F in neutrophils is required for the response to immune checkpoint blockade therapy

22 Feb 2025

Abstract excerpt

Tumor-associated neutrophils (TANs) represent a significant barrier to the effectiveness of immune checkpoint blockade (ICB) therapy. A comprehensive understanding of TANs' regulatory mechanisms is therefore essential for predicting ICB efficacy and improving immunotherapy strategies. Our study reveals that MYO1F is selectively downregulated in neutrophils within both human cancers and murine tumor models,...

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PMID: 40202509
DOI: 10.1084/jem.20241957

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