Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Common Brain Protein and Genetic Loci Between Parkinson's Disease and Lewy Body Dementia.

CNS neuroscience & therapeutics - 1 Apr 2025

Jia Tingting, Yang Fuhua, Qin Fengqin, He Yongji, Han Feng, Zhang Chengcheng

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) and Lewy body dementia (LBD) have many common features, including clinical manifestations, neurochemistry, and pathology, but little is known about their shared brain proteins and genetic factors. METHODS: To identify susceptibility-related brain proteins that are shared between PD and LBD patients, proteome-wide association studies (PWASs) were conducted by integrating human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Brain
Share to Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Lewy Body Disease

Share to Nerve Tissue Proteins

Share to Parkinson Disease

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 40202048
DOI: 10.1111/cns.70370
PMCID: PMC11979625

Genes

TMEM175
DOC2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Common Brain Protein and Genetic Loci Between Parkinson's Disease and Lewy Body Dementia.PMID 40202048Read ↗

Shared mechanisms across the major psychiatric and neurodegenerative diseases.Semantic proximity Read ↗

Identification of circulatory neuro-related proteins in Parkinson's disease: an integrated genetic-proteomic-clinical study.Semantic proximity Read ↗

Expanding causal genes for Parkinson’s disease via multi-omics analysisSemantic proximity Read ↗

Brain Proteome-Wide and Transcriptome-Wide Asso-ciation Studies, Bayesian Colocalization, and Mendelian Randomization Analyses Reveal Causal Genes of Parkinson's Disease.Semantic proximity Read ↗

Joint analysis of proteome, transcriptome, and multi-trait analysis to identify novel Parkinson's disease risk genes.Semantic proximity Read ↗

Pinpointing novel risk loci for Lewy body dementia and the shared genetic etiology with Alzheimer’s disease and Parkinson’s disease: a large-scale multi-trait association analysisSemantic proximity Read ↗

Sex-Stratified Multi-Omics Identifies Sexually Dimorphic Molecular Targets in Parkinson’s DiseaseSemantic proximity Read ↗

Genetic risk factor clustering within and across neurodegenerative diseasesSemantic proximity Read ↗

Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s diseaseSemantic proximity Read ↗

Sex-biased Genetic Risk Loci and Causal Brain Proteins in Parkinson’s DiseaseSemantic proximity Read ↗

Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease.Semantic proximity Read ↗

Network proteomics of the Lewy body dementia brain reveals presynaptic signatures distinct from Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.