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Article

Mutational landscape of atherosclerotic plaques reveals large clonal cell populations.

JCI insight - 22 May 2025

Steffensen Lasse Bach, Kavan Stephanie, Jensen Pia Søndergaard, Pedersen Matilde Kvist, Bøttger Steffen Møller, Larsen Martin Jakob, Dembic Maja, Bergman Otto, Matic Ljubica, Hedin Ulf, Andersen Lars van Brakel, Lindholt Jes Sanddal, Houlind Kim Christian, Riber Lars Peter, Thomassen Mads, Rasmussen Lars Melholt

Abstract excerpt

The notion of clonal cell populations in human atherosclerosis has been suggested but not demonstrated. Somatic mutations are used to define cellular clones in tumors. Here, we characterized the mutational landscape of human carotid plaques through whole-exome sequencing to explore the presence of clonal cell populations. Somatic mutations were identified in 12 of 13 investigated plaques, while no mutations were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40198128
DOI: 10.1172/jci.insight.188281
PMCID: PMC12128991

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