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The single-cell spatial landscape of stage III colorectal cancers

6 Apr 2025

Abstract excerpt

We conducted a spatial analysis of stage III colorectal adenocarcinomas using Hyperion Imaging Mass Cytometry, examining 52 tumors to assess the tumor microenvironment at the single-cell level. This approach identified 10 distinct cell phenotypes in the tumor microenvironment, including stromal and immune cells, with a subset showing a proliferative phenotype. By focusing on spatial neighborhood interactions and...

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Cancer Immunotherapy and Biomarkers
Genetic factors in colorectal cancer
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40189697
DOI: 10.1038/s41698-025-00853-5

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