Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapse

6 Apr 2025

Abstract excerpt

Graft-versus-host disease (GVHD) and relapse are major complications following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Metabolites play crucial roles in immune regulation, but their causal relationships with GVHD and relapse remain unclear. We utilized genetic variants from genome-wide association studies (GWAS) of 309 known metabolites as instrumental variables to evaluate their causal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Hematopoietic Stem Cell Transplantation
Share to Hemoglobinopathies and Related Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40189523
DOI: 10.1186/s12916-025-04026-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mendelian randomization analysis of blood metabolites and immune cell mediators in relation to GVHD and relapsePMID 40189523Read ↗

Plasma metabolites as mediators in immune cell-pancreatic cancer risk: insights from Mendelian randomization.Semantic proximity Read ↗

Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolitesSemantic proximity Read ↗

Genetically predicted blood metabolites mediate the association between circulating immune cells and pancreatic cancer: A Mendelian randomization study.Semantic proximity Read ↗

Identifying serum metabolite biomarkers for autoimmune diseases: a two-sample mendelian randomization and meta-analysisSemantic proximity Read ↗

Causal association between plasma metabolites and diverse autoimmune diseases: a two-sample bidirectional mendelian randomization study.Semantic proximity Read ↗

Causal relationships between immunophenotypes, plasma metabolites, and temporomandibular disorders based on Mendelian randomization.Semantic proximity Read ↗

Causal insights into immune cell profiles, plasma metabolites, and bladder cancer: A Mendelian randomization approach.Semantic proximity Read ↗

The relationship between metabolite mediated immune regulatory imbalance and the occurrence of malignant tumors of bone and articular cartilage: a Mendelian randomization study.Semantic proximity Read ↗

Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization.Semantic proximity Read ↗

Causal effects of plasma metabolites on autoimmune hepatitis (AIH): a bidirectional two-sample mendelian randomization study.Semantic proximity Read ↗

Genetically predicted metabolites mediate the association between immune cells and metabolic dysfunction-associated steatotic liver disease: a mendelian randomization study.Semantic proximity Read ↗

Causal relationships of metabolites with allergic diseases: a trans-ethnic Mendelian randomization studySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.