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Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites

13 Dec 2019

Abstract excerpt

Despite improvement in clinical management, allogeneic hematopoietic stem cell transplantation (HSCT) is still hampered by high morbidity and mortality rates, mainly due to graft versus host disease (GvHD). Recently, it has been demonstrated that the allogeneic immune response might be influenced by external factors such as tissues microenvironment or host microbiota. Here we used high throughput metabolomics to...

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PMID: 31836702
DOI: 10.1038/s41467-019-13498-3

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