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Article

Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence

1 Dec 2016

Abstract excerpt

BACKGROUND: In culturing normal diploid cells, senescence may either happen naturally, in the form of replicative senescence, or it may be a consequence of external challenges such as oxidative stress. Here we present a comparative analysis aimed at reconstruction of molecular cascades specific for replicative (RS) and stressinduced senescence (SIPS) in human fibroblasts. RESULTS: An involvement of...

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PMID: 28105936
DOI: 10.1186/s12864-016-3352-4

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